P. R. Lichtlen (auth.), Professor Dr. P. R. Lichtlen,'s Adalat: A Comprehensive Review PDF

By P. R. Lichtlen (auth.), Professor Dr. P. R. Lichtlen, Professor Dr. A. Reale (eds.)

ISBN-10: 3642854982

ISBN-13: 9783642854989

ISBN-10: 3642855008

ISBN-13: 9783642855009

As little as 30 years in the past, cardiovascular learn at Bayer used to be only a small sideline with in an atmosphere ruled through chemotherapy study, and basically 15 years in the past, Bayer's pharmaceutical enterprise was once limited to ecu and Latin Ameri­ can nations, with revenues in cardiovascular prescribed drugs with reference to 0. It is going with no announcing that Adalat has replaced the corporate as an entire in its study, improvement, and advertising, either in Germany and, most significantly, international­ broad. In examine and improvement, Adalat has led the best way in to new components akin to high blood pressure, acute neurology, dementia, atherosclerosis, and middle failure. In pharmacology, Adalat was once current on the dawning of the second one phar­ macological revolution, which began from entire animal versions and progres­ sed, through in vitro screening and pharmacological learn at the DHP receptor, all the way down to the molecular point with the cloning of calcium-channel proteins. Having the Adalat tale heavily in its early years as a bench scientist, allow me take this chance to thank the inventors, the scientists, and the investigators who've helped to faucet the extensive strength of calcium-channel blockade with dihyd­ ropyridines often and Adalat specifically. yet, luck will not be vague our imaginative and prescient. there is not any cause of us to relaxation on our laurels: it's going to take actual suggestions in cardiovascular study to most sensible the most suitable set by way of Adalat. allow us to absorb the challenge.

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As low as 30 years in the past, cardiovascular examine at Bayer was once only a small sideline with in an atmosphere ruled by means of chemotherapy examine, and basically 15 years in the past, Bayer's pharmaceutical enterprise was once restricted to ecu and Latin Ameri­ can international locations, with revenues in cardiovascular prescription drugs just about 0.

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Arteriosclerosis 7: 80-87 14. Habib 18, Bossaler C, Wells S, Williams C, Morrisett JD, Henry PD (1986) Preservation of endothelium-dependent vascular relaxation in cholesterol-fed rabbit by treatment with the calcium blocker PN 200110. Circ Res 58:305-309 15. Moore 18, Fuller BL, Falotico R, Toman EL (1985) Inhibition of rabbit platelet phosphodiesterase activity and aggregation by calcium channel blockers. Thromb Res 40:401-411 16. Daugherty A, Rateri DL, Schonfeld G, Sobel BE (1987) Inhibition of choleteryl ester deposition in macrophages by calcium entry blockers: an effect dissociable from calcium entry blockade.

Even in the early stages of work with the heart, the Fleckenstein group demonstrated the crucial role of calcium overload in the production of noncoronarogenic cardiac necrosis and its prevention by the first calcium antagonists verapamil, D600, and prenylamine. Later on, they described the protective effect of calcium antagonists against arterial media calcification in Monckeberg's type of arteriosclerosis produced by dihydrotachysterol or vitamin D. Obviously, calcium overload induced by vitamin D3 poisoning or by a magnesium-deficient regimen starts a common pathogenic mechanism that leads to both myocardial necrotization and calcinotic arterial media destruction [25].

Schmitz G, Robenek H et al. (1988) Ca++ antagonists and ACAT inhibitors promote cholesterol efflux from macrophages by different mechanisms. Arteriosclerosis 8:46-56 18. Etingin OR, Hajjar DP (1985) Nifedipine increases cholesteryl ester hydrolytic activity in lipid-laden rabbit arterial smooth muscle cells. J Clin Invest 75:1554-1558 19. Nomoto A, Hirosumi J, Sekiguchi C, Mutoh S, Yamaguchi I, Aoki H (1987) Antiatherogenic activity of FR34235 (Nilvadipine) a new potent calcium antagonist. Atherosclerosis 64:255-261 20.

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Adalat: A Comprehensive Review by P. R. Lichtlen (auth.), Professor Dr. P. R. Lichtlen, Professor Dr. A. Reale (eds.)


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