Advances in neuroregulation and neuroprotection - download pdf or read online

By Collin, Catherine

ISBN-10: 9047415108

ISBN-13: 9789047415107

ISBN-10: 9067644129

ISBN-13: 9789067644129

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Advances in Neuwregulation and Neuroprotection (2005), pp. etal (Eds) © VSP 2005 Alzheimer's disease: from bench to bedside MOHAMMAD SAEEDl<*, PHILIPPE M. PARVEZ2 1 Department of Biological and Biomedical Sciences, The Aga Khan University, Stadium Road, Karachi 74800, Pakistan Developmental Neuroendocrinology and Neuropharmacology Unit, Institute Alfred Fessard for Neurosciences, CNRS, Gif sun Yrelte, France Abstract—Alzheimer's disease (AD) is the most common cause of dementia worldwide. It causes major debility for the elderly with medical, social and economic implications.

Lett. 29, 261-264. Forner, M. , Barriga, C, Rodriguez, A. , et al. (1995). A study of the role of corticosterone as a mediator in exercise-induced stimulations of murine macrophage phagocytosis, J. Physiol. 488, 789-794. 28 C. Barriga et al. Khansari, D. , Murgo, A. J. and Faith, R. E. (1990). Effects of stress on the immune system, Immunology Today 11, 170-175. Maestroni, G. J. M. (1993). The immunoendocrine role of melatonin, J. Pineal Res. 14, 121-126. Maestroni, G. J. M. and Conti, A. (1991).

1986, 1987; Maestroni etal, 1988; Maestroni andConti, 1991). Indeed, Maestroni (1993) noted the possibility that melatonin acts as a 'buffer' in stress situations to neutralize 26 C. Barriga et al. the adverse immunological effects produced by the circadian release of glucocorticoids. , 2001), and that in vitro incubation with physiological concentrations of corticosterone and melatonin leads to variations in phagocyte activity (Rodriguez et al, 2001; Barriga et al, 2002). Given these antecedents, and that there have been relatively few published works addressing the question of whether these hormones intervene directly in the activation of the non-specific immune response, we carried out the present in vitro study to evaluate the effect of pharmacological concentrations of melatonin and corticosterone, separately and conjointly, on the phagocytic activity triggered by the ingestion of antigens in macrophages from mice subjected to forced swimming (the group of stressed animals), and from mice not subjected to any activity (basal animals).

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Advances in neuroregulation and neuroprotection by Collin, Catherine


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